Domperidone causes a psychological side effect


Some rare side effects may occur with the use of Motilium that make it necessary to stop treatment and contact a doctor immediately. Detailed information can be found in the section “What side effects can Motilium have?”.

When should Motilium not be used?

You must not use Motilium:

  • if you are allergic (hypersensitive) to the active substance or any of the ingredients (e.g. rash, itching, shortness of breath or facial swelling).
  • if you have a disease of the pituitary gland called prolactinoma.
  • if you have severe gastrointestinal diseases (bleeding, mechanical obstruction or perforation of the intestine). Such illnesses can manifest themselves in the form of severe abdominal cramps or persistent dark stools.
  • if you have or have had liver disease.
  • if your electrocardiogram (EKG) suggests a heart problem called "prolonged QT interval".
  • if you have or have had a problem where your heart cannot pump blood around your body as well as it should (heart failure).
  • if you have a problem where you have low potassium or magnesium levels, or high potassium levels in your blood.
  • if you are taking the following medicines at the same time, which can inhibit the liver enzyme CYP3A4, slow down the metabolism of other medicines in the body or affect your heart rhythm:
  • certain drugs (so-called azole antimycotics) used to treat fungal infections such as itraconazole, ketoconazole, posaconazole or voriconazole;
  • certain antibiotics such as erythromycin, clarithromycin, or telithromycin, which are used against bacterial infections;
  • certain medicines for HIV virus infections (HIV proteinase inhibitors) such as ritonavir or saquinavir.

Motilium film-coated tablets are not suitable for children under 12 years of age, adults and adolescents who weigh less than 35 kg.

Motilium Suspension is not suitable for infants and children under 12 years of age who weigh less than 35 kg.

In what circumstances is caution necessary when taking / using Motilium?

Particular care should be taken when giving Motilium to young children: the risk of neurological side effects (such as involuntary movements) is higher in young children. Therefore, Motilium may only be given to children under the age of twelve after a thorough medical examination and under strict medical supervision.

The oral suspension should be used in children to avoid overdose.

Strict adherence to the dose and duration of intake prescribed by the doctor is essential.

If you are taking other medicinal products (including preparations made from medicinal plants) at the same time, it is imperative that you discuss this with your doctor or pharmacist, as Motilium takes medicinal products that affect a certain protein, the liver enzyme CYP-3A4, at the same time , can lead to interactions.

You should tell your doctor if you have had heart problems in the past or are currently suffering from any heart disease, including heart failure (heart failure), heart attack, angina pectoris, or irregular heartbeat (fast, slow or irregular heartbeat).

If you experience an abnormal heart rhythm during treatment, you should stop treatment with Motilium and contact your doctor immediately.

Patients at increased risk of certain irregular heartbeat (QT prolongation) should talk to their doctor before taking Motilium.

Motilium should not be used in patients with liver disease.

Your doctor may adjust the dose in patients with kidney disease, especially if you are taking Motilium for a long time.

Special dosage forms

Tell your doctor if you are taking medicines that reduce stomach acid. Motilium film-coated tablets and suspension should not be taken at the same time as medicines that reduce gastric acidity. Take Motilium film-coated tablets resp. the suspension before and the anti-gastric acid medicine after the meal.

Motilium film-coated tablets

The film-coated tablets contain lactose and are therefore not suitable for patients with lactose intolerance (= inability to digest lactose, a sugar found in milk and dairy products), galactosemia (occurrence of galactose in the blood) or glucose-galactose malabsorption syndrome (= Metabolic disorder with inability to digest carbohydrates and sugars that occur in food including starch, milk and dairy products).

Motilium suspension

The suspension contains sorbitol and is not suitable for patients who are intolerant to sorbitol or who have a familial fructose intolerance (fructose occurs in fruits and fruit juices).

Tell your doctor if you are taking anticholinergics (medicines used to treat allergies, asthma, incontinence, gastrointestinal cramps, muscle spasms, depression, or sleep disorders such as dextromethorphan or diphenhydramine) as these could affect Motilium.

Do not drive or use machines if you feel tired, sleepy, or dizzy after taking your medicine.

Tell your doctor or pharmacist if you

Are taking medicines to treat fungal or bacterial infections, heart problems, malaria, AIDS / HIV, depression, mental illness, gastrointestinal problems, cancer, pain, or addiction;

Take aprepitant, a medicine used to relieve nausea associated with chemotherapy.

Your doctor will decide whether these medicines can be taken with Motilium or whether you need to be closely monitored for heart problems.

Inform your doctor or pharmacist if you suffer from other illnesses, have allergies or are taking other medicines (including those you have bought yourself!).

Can Motilium be used during pregnancy or breastfeeding?


It is not known whether Motilium will harm you during pregnancy. If you are pregnant or think you may be pregnant, ask your doctor who will decide whether you can take Motilium.


Small amounts of Motilium have been found in breast milk. Use in nursing mothers is therefore not recommended.